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Updated: Aug 16, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
[Acute left heart failure after interventional occlusion of an atrial septal defect]
P Ewert1, F Berger, N Nagdyman
1Abteilung für Angeborene Herzfehler Deutsches Herzzentrum Berlin Augustenburger Platz 1 13353 Berlin, Germany. ewert@dhzb.de
Insights
Transcatheter closure of atrial septal defects (ASDs) can precipitate acute left ventricular failure in elderly patients. This case highlights a rare complication, emphasizing the need for careful patient selection and monitoring after ASD device closure.
Area of Science:
- Cardiology
- Interventional Cardiology
- Heart Failure Research
Background:
- Congestive left ventricular failure is a known complication following surgical closure of atrial septal defects (ASDs), particularly in elderly individuals.
- Transcatheter closure of ASDs is a common procedure, but potential complications require ongoing investigation.
Observation:
- A 78-year-old woman with a history of an atrial septal defect (ASD) and preserved left ventricular function underwent successful transcatheter closure using an Amplatzer Septal Occluder.
- Two hours post-procedure, the patient developed acute pulmonary edema and left ventricular failure, characterized by a significant increase in end-diastolic diameter and a drop in ejection fraction.
Findings:
- The patient required mechanical ventilation and inotropic support for several days due to severe left ventricular failure.
- Diuretic therapy was administered until ejection fraction improved, and the patient was hospitalized for two weeks post-intervention.
- This represents a novel case of left ventricular failure occurring after transcatheter ASD closure.
Implications:
- Reduced preload over decades may contribute to impaired ventricular compliance, predisposing elderly patients to acute left ventricular failure after ASD closure.
- This case underscores the importance of considering ventricular compliance and potential hemodynamic shifts in elderly patients undergoing atrial septal defect closure.
- Further research is warranted to identify risk factors and optimize management strategies for preventing left ventricular failure post-ASD closure.
Abstract:
Congestive left ventricular failure after surgical closure of an atrial septal defect (ASD) has been repeatedly reported, particularly in the elderly. We present a case of left ventricular failure after a successful transcatheter closure of an ASD, which to our knowledge has not been described before. In a 78-year-old woman (50 kg, 160 cm) with well-preserved left ventricular function (ejection fraction 65%) and without coronary artery disease or arterial hypertension, an ASD (Qp/Qs 1.6:1) was closed with an Amplatzer Septal Occluder without a residual shunt. Two hours after the procedure, she developed pulmonary edema due to left ventricular failure (increase of end-diastolic diameter from 42 mm to 54 mm, ejection fraction 20%), had to be mechanically ventilated for 24 hours and needed catecholamines for 4 days. High doses of diuretics were supplied until the ejection fraction normalized (32%). The patient could not be discharged until two weeks after intervention. A reduced preload for decades may predispose acute left ventricular failure, particularly in the elderly with compromised ventricular compliance.
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