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Implants in regenerated bone in a primate model.

M E Fritz¹, M K Jeffcoat, M Reddy

¹Yerkes Regional Primate Research Center, Emory University, Atlanta, GA, USA.

Journal of Periodontology

|July 17, 2001

Summary

Dental implants can be successfully placed in bone regenerated using guided bone regeneration (GBR) techniques. This study in primates shows regenerated bone supports implants as effectively as native bone, with similar bone-to-implant contact after loading.

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Area of Science:

Oral surgery
Regenerative medicine
Dental implantology

Background:

Guided bone regeneration (GBR) was previously used to repair large mandibular bone defects in primates.
This study investigates implant placement and loading in GBR-treated bone.

Purpose of the Study:

To evaluate the long-term success of root-form implants placed in GBR-created regenerated bone.
To compare implant performance in regenerated bone versus native bone.

Main Methods:

Standardized mandibular defects (8 x 19 mm) were created in 9 primates.
Reinforced ePTFE membranes were used for GBR, with implants placed 12 months post-regeneration.
Implants were loaded with prostheses for 12 months and compared to implants in non-regenerated bone.

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Main Results:

Implants in regenerated bone exhibited comparable radiological and histomorphometric characteristics to those in native bone.
Bone-to-implant contact percentages were similar: 65% in regenerated bone vs. 59% in non-regenerated bone.

Conclusions:

Root-form implants placed in GBR-regenerated primate bone demonstrate equivalent outcomes to implants in non-regenerated bone.
GBR is a viable method for bone augmentation to support dental implants.