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Related Experiment Videos

Normal tension glaucoma and primary open angle glaucoma associated with increased platelet aggregation.

M Matsumoto1, H Matsuhashi, M Nakazawa

  • 1Department of Ophthalmology, Hirosaki University School of Medicine, Japan. mitsu-ma@gc4.so-net.ne.jp

The Tohoku Journal of Experimental Medicine
|July 17, 2001
PubMed
Summary

Glaucoma patients frequently exhibit abnormal platelet aggregation, particularly those with normal tension glaucoma (NTG). This study highlights increased platelet reactivity as a potential factor in glaucoma development.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Vascular Biology

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Platelet aggregation and fibrinolytic systems play crucial roles in vascular health.
  • Understanding these systems may offer insights into glaucoma pathogenesis.

Purpose of the Study:

  • To evaluate platelet aggregation and fibrinolytic activity in patients with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG).
  • To compare these hemostatic parameters between glaucoma subtypes and healthy controls.

Main Methods:

  • Photoelectrophotometric analysis of adenosine diphosphate (ADP) or collagen-induced platelet aggregation.
  • Measurement of prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin-antithrombin III complex (TAT), and alpha2 plasmin inhibitor-plasmin complex.

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  • Comparison of results between 22 NTG patients, 13 POAG patients, and 42 controls.

    • Main Results:

    • Abnormal secondary platelet aggregation was observed in 77% of NTG patients and 38% of POAG patients, significantly higher than controls.
    • Increased platelet aggregation tendency was more pronounced in NTG compared to POAG.
    • Fibrinolytic parameters were within normal ranges, though log10(TAT) was higher in NTG.

    Conclusions:

    • Elevated platelet aggregation, indicated by abnormal secondary aggregation in vitro, is frequently associated with glaucoma.
    • This heightened platelet reactivity is more apparent in normal tension glaucoma than in primary open-angle glaucoma.
    • Platelet function may represent a significant contributing factor in the pathophysiology of certain glaucoma types.