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Experimental diminution fo splenci function by selective embolization of the splenic artery
Surgery, Gynecology & Obstetrics
|May 1, 1975
Summary
Selective splenic artery embolization using Amicar-mixed clot or Gelfoam showed different effects on hematologic function and spleen appearance in dogs. Gelfoam resulted in prolonged splenic dysfunction and fibrosis compared to Amicar-mixed clot.
Area of Science:
- Interventional Radiology
- Veterinary Medicine
- Hematology
Background:
- Splenic artery occlusion is a potential therapeutic option for patients unsuitable for splenectomy.
- Understanding the differential effects of embolic agents is crucial for clinical application.
Purpose of the Study:
- To compare the efficacy and impact of Amicar-mixed clot versus Gelfoam in selective splenic artery embolization.
- To evaluate the resultant splenic function and histological changes post-embolization.
Main Methods:
- Selective splenic artery embolization was performed in 18 dogs using either Amicar-mixed clot or Gelfoam.
- Angiography was conducted pre- and post-embolization, and at sacrifice.
- Hematologic parameters (white blood cell count, hematocrit) were monitored weekly in dogs sacrificed at two months.
Main Results:
- Amicar-mixed clot led to transient hematologic depression due to lysis and peripheral displacement, with spleens returning to normal appearance.
- Gelfoam caused prolonged hematologic dysfunction and moderate splenic parenchymal fibrosis, despite peripheral embolization.
Conclusions:
- Selective splenic artery embolization can depress splenic function.
- Gelfoam appears to induce more persistent splenic dysfunction and fibrosis than Amicar-mixed clot.