Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Viruses and apoptosis.

B J Thomson1

  • 1University of Nottingham, Nottingham City Hospital, Nottingham, UK.

International Journal of Experimental Pathology
|July 17, 2001
PubMed
Summary
This summary is machine-generated.

Viruses have evolved mechanisms to control programmed cell death (apoptosis) in host cells, impacting viral replication and oncogenesis. Studying these viral strategies enhances our understanding of apoptosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelet function testing in patients with post-operative tonsillectomy bleeding may be a useful early identifier of inherited platelet function disorders.

The Journal of laryngology and otology·2020
Same author

Short-term changes observed in multiparametric liver MRI following therapy with direct-acting antivirals in chronic hepatitis C virus patients.

European radiology·2018
Same author

Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells.

Clinical and experimental immunology·2013
Same author

Clinical trial: a primary-care-based model for the delivery of anti-viral treatment to injecting drug users infected with hepatitis C.

Alimentary pharmacology & therapeutics·2008
Same author

Response rates to combination therapy for chronic HCV infection in a clinical setting and derivation of probability tables for individual patient management.

Journal of viral hepatitis·2007
Same author

A closer look at water-related geologic activity on Mars.

Science (New York, N.Y.)·2007
Same journal

Exosomal miR-221-3p derived from bone marrow mesenchymal stem cells alleviates endoplasmic reticulum stress-mediated apoptosis in nucleus pulposus cells via the Nrf2/HO-1 signalling pathway.

International journal of experimental pathology·2025
Same journal

Effect of pulmonary arterial hypertension on the morphology and antioxidant defence of the ventral prostate of sedentary and exercised rats.

International journal of experimental pathology·2025
Same journal

Correction to 'The Energy Density of Laser Light Differentially Modulates the Skin Morphological Reorganization in a Murine Model of Healing by Secondary Intention'.

International journal of experimental pathology·2025
Same journal

Roles of long non-coding RNAs in oesophageal cancer pathogenesis.

International journal of experimental pathology·2025
Same journal

Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism.

International journal of experimental pathology·2025
Same journal

Molecular epidemiology of Epstein-Barr virus in gastric cancer patients compared to healthy control group in Shiraz, Iran.

International journal of experimental pathology·2025
See all related articles

Area of Science:

  • Cell Biology
  • Virology
  • Immunology

Background:

  • Apoptosis, or programmed cell death, is a fundamental biological process crucial for development and tissue homeostasis.
  • Cells often undergo apoptosis in response to viral infections, limiting virus propagation.
  • Viruses have developed diverse strategies to evade or manipulate host cell apoptosis.

Purpose of the Study:

  • To review the process of apoptosis and its significance in multicellular organisms.
  • To explore how viral interactions with apoptosis have advanced our understanding of programmed cell death.
  • To detail specific viral mechanisms that interfere with host cell death pathways.

Main Methods:

  • Literature review focusing on viral modulation of apoptosis.
  • Analysis of conserved effector mechanisms and mammalian-specific regulatory pathways.

Related Experiment Videos

  • Case studies of viral gene products impacting programmed cell death.

    • Main Results:

    • Viruses interfere with both conserved and host-specific apoptosis pathways.
    • Viral inhibition of apoptosis provides a survival advantage for the virus.
    • Preventing apoptosis is critical for oncogenic virus-induced host cell transformation.

    Conclusions:

    • The study of viruses provides critical insights into the complex mechanisms of apoptosis.
    • Viral interference with apoptosis highlights the intricate interplay between viruses and host cell machinery.
    • Understanding these interactions is key to comprehending viral pathogenesis and oncogenesis.