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Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

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Published on: February 24, 2014

Common hereditary cancers and implications for primary care.

J Emery1, A Lucassen, M Murphy

  • 1General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, Forvie Site, CB2 2SR, Cambridge, UK. jde10@medschl.cam.ac.uk

Lancet (London, England)
|July 17, 2001
PubMed
Summary

Genetic discoveries identify high-risk individuals for hereditary cancers. Primary care needs strategies to manage genetic risk and guide appropriate genetic testing and surveillance.

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Area of Science:

  • Medical Genetics
  • Oncology
  • Primary Care Medicine

Background:

  • Advances in identifying genes for hereditary breast, ovarian, and colorectal cancers have increased public and clinical awareness.
  • This has led to a rise in referrals for genetic counseling, surgical consultation, and genetic testing.

Purpose of the Study:

  • To review evidence for managing individuals at increased risk of hereditary cancers.
  • To highlight uncertainties and discuss implications for primary care practice.
  • To focus on common inherited cancers with significant future clinical impact.

Main Methods:

  • Review of published evidence on the management of hereditary cancer risk.
  • Focus on common inherited cancer syndromes.
  • Discussion of implications for primary care integration of genetic medicine.

Main Results:

  • Increased identification of individuals at genetic risk for common cancers.
  • Growing demand for genetic testing and surveillance strategies.
  • Areas of uncertainty in current management protocols exist.

Conclusions:

  • Genetic discoveries are transforming cancer predisposition understanding and clinical practice.
  • Primary care practitioners require support to effectively identify and manage patients with increased hereditary cancer risk.
  • Developing strategies for integrating genetic medicine into primary care is crucial for optimal patient care and resource allocation.