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Related Experiment Videos

Aortic valve allografts for mitral valve replacement.

E B Stinson, R B Griepp, C P Bieber

    Surgery
    |June 1, 1975
    PubMed
    Summary
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    Composite valve graft versus separate aortic valve and ascending aortic replacement: is there still a role for the separate procedure?

    Circulation·1997

    Fresh aortic valve allografts for mitral valve replacement showed good initial survival and functional improvement. However, high rates of valve dysfunction limit their long-term clinical use.

    Area of Science:

    • Cardiovascular Surgery
    • Thoracic Surgery
    • Biomedical Engineering

    Background:

    • Mitral valve replacement is a critical procedure for severe mitral regurgitation or stenosis.
    • Allograft valves offer potential advantages but long-term durability remains a concern.

    Purpose of the Study:

    • To evaluate the long-term outcomes of mitral valve replacement using fresh aortic valve allografts on rigid support rings.

    Main Methods:

    • A cohort of 122 patients underwent mitral valve replacement between 1967 and 1971.
    • Follow-up data, including survival, functional class, thromboembolism, and valve dysfunction, were analyzed.

    Main Results:

    • Operative mortality was 6.6%. 5-year survival was 71%. Functional class improved significantly (2.9 to 1.6).

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  • Thromboembolism occurred at 7% per patient-year. Allograft valve dysfunction developed in 64 patients (13% per patient-year), requiring reoperation in 16.

    • Conclusions:

    • Mitral valve replacement with fresh aortic allografts provides functional improvement and low thromboembolism rates.
    • The high incidence of time-related allograft valve dysfunction is unacceptable, precluding further clinical use.