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A novel method for the preparation of amino-substituted hypocrellin B
1Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China.
Bioorganic & Medicinal Chemistry Letters
|July 17, 2001
Abstract:
A series of amino-substituted hypocrellins derived from hypocrellin B (HB) were synthesized by a novel mild method, in which the peri-hydroxylated perylenequinone structure of hypocrellin was preserved by the reaction of HB with an amine. The red absorption of the resulting products was significantly enhanced relative to the parent hypocrellins, which will significantly improve its photodynamic therapy effectiveness.