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Related Experiment Videos

Venous leg ulcers and microcirculation.

A Steins1, M Hahn, M Jünger

  • 1Department of Dermatology, University Hospital, Tübingen, Germany. anke.steins@med.uni-tuebingen.de

Clinical Hemorheology and Microcirculation
|July 17, 2001
PubMed
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Venous valve incompetence alone doesn't cause leg skin changes. However, retrograde pressure waves and reduced capillary density correlate with severe trophic changes and impact venous ulcer healing.

Area of Science:

  • Vascular Medicine
  • Dermatology
  • Microcirculation Research

Background:

  • Venous valve incompetence is a common condition.
  • Trophic skin changes and venous leg ulcers are severe manifestations.
  • The underlying microcirculatory mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the relationship between venous valve incompetence and lower limb trophic skin changes.
  • To assess microcirculatory parameters in patients with severe venous disease.
  • To determine the prognostic impact of microangiopathy on venous ulcer healing.

Main Methods:

  • Utilized "servo nulling" pressure measurement during simulated calf muscle contraction.
  • Measured retrograde pressure waves in nutritive skin capillaries.

Related Experiment Videos

  • Assessed capillary density and transcutaneous oxygen partial pressure.

    • Main Results:

    • Retrograde pressure waves were detected in capillaries of patients with dermatoliposclerosis or venous leg ulcers.
    • A strong correlation exists between trophic skin changes, capillary density, and cutaneous oxygen partial pressure.
    • Improvement in cutaneous microangiopathy was necessary for venous ulcer healing.

    Conclusions:

    • Venous valve incompetence alone does not cause trophic skin changes.
    • Microcirculatory dysfunction, indicated by retrograde pressure waves and reduced capillary density, is crucial in severe venous disease.
    • Capillary density and transcutaneous oxygen partial pressure are significant prognostic indicators for venous ulcer healing.