Venous leg ulcers and microcirculation
Related Experiment Video
Updated: Oct 5, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
1Department of Dermatology, University Hospital, Tübingen, Germany. anke.steins@med.uni-tuebingen.de
Abstract:
Incompetence of venous valves do not lead per se to trophic skin changes of the lower limb. In severely concerned patients suffering from dermatoliposclerosis or venous leg ulcers retrograde pressure waves were detected in the nutritive capillaries of the skin by the "servo nulling" pressure measurement during simulated calf muscle contraction. Between the degree of trophic skin change and the capillary density and cutaneous oxygen partial pressure a close correlation was found. Healing of venous ulcers occurred only if the cutaneous microangiopathy in the ulcer area improved. Capillary density and transcutaneous oxygen partial pressure were of prognostic impact as to healing of venous ulcers.
Related Concept Videos
Varicose Veins I: Introduction
Diabetic Foot Ulcer
Venous Thrombosis IV: Nursing Management
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies