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Related Experiment Videos

Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development.

R Al-Shawi1, S V Ashton, C Underwood

  • 1Department of Anatomy and Developmental Biology, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK.

Development Genes and Evolution
|July 17, 2001
PubMed
Summary

ROR1 and ROR2 receptor tyrosine kinases show distinct expression patterns during mouse development. Their expression domains overlap but also differ significantly across various organ systems and germ layers.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • ROR1 and ROR2 are orphan receptor tyrosine kinases.
  • They are closely related to MuSK and Trk neurotrophin receptors.

Purpose of the Study:

  • To extensively survey the expression patterns of ROR1 and ROR2 during mouse embryonic development.
  • To understand the spatial and temporal expression differences and overlaps between ROR1 and ROR2.

Main Methods:

  • In situ hybridization was used to analyze gene expression.
  • Mouse embryos at various developmental stages (E8.5-E14.5) were examined.

Main Results:

  • ROR2 expression is broader than ROR1 at early stages (E8.5-E9.5), with ROR1 mainly in head mesenchyme.

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  • At later stages (E12.5-E14.5), ROR1 expression expands while ROR2 becomes more restricted.
  • Expression domains overlap, but ROR1 is often a subset of ROR2 expression, or they show complementary patterns.
  • Both genes are expressed in derivatives of all three germ layers and across most organ systems, notably in sense organs and neural crest derivatives.

    • Conclusions:

    • ROR1 and ROR2 exhibit dynamic and distinct expression profiles throughout mouse development.
    • Their differential and overlapping expression suggests complex roles in the development of multiple organ systems, including the nervous system and sensory organs.