Hypertension and medication-related renal dysfunction in the HIV-infected patient

Given the improved life expectancy with highly active antiretroviral therapy among patients with human immunodeficiency virus (HIV)-infection, the treatment of medical problems such as hypertension will become increasingly more important. Although HIV-infected patients are at increased risk for the development of pulmonary hypertension, there is little data to suggest they are at increased risk for systemic hypertension or secondary causes of hypertension. Multiple potential drug interactions exist between antiretroviral medications, particularly the protease inhibitors and antihypertensive medications. Additionally, certain antiretroviral medications have frequent and important side effects relating to the kidneys and urinary system. Knowledge of these interactions and side effects is essential toward caring for the patient with HIV-infection.