[Morphometric parameters of nuclei in EBV-positive and EBV-negative Hodgkin's lymphoma]

Five morphometric parameters of nuclei of EBV-positive and EBV-negative Hodgkin's lymphoma cells were assessed for length, width, area, circumference, and circularity. For the measurement of the nuclei of the tumor cells (Hodgkin, Reed-Sternberg cells) the system of image analysis "Lucie" was used. In comparison with EBV-positive Reed-Sternberg cells, the nuclei of the EBV-negative Reed-Sternberg cells had significantly larger circumference, area and width. The nuclei of the Hodgkin cells in EBV-negative Hodgkin's lymphomas had significantly larger width and circularity. The authors assume that the altered morphometric parameters are related to a latent EBV infection.