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Related Experiment Videos

Halofantrine-phospholipid interactions: monolayer studies.

M L Go1, S S Feng

  • 1Department of Pharmacy, National University of Singapore, Singapore. phagoml@nus.edu.sg

Chemical & Pharmaceutical Bulletin
|July 18, 2001
PubMed
Summary
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The antimalarial drug halofantrine readily penetrates dipalmitolylphosphatidylcholine (DPPC) lipid monolayers, affecting their surface properties. Cholesterol hinders this penetration, particularly in certain lipid phases.

Area of Science:

  • Biophysics
  • Pharmacology
  • Materials Science

Background:

  • Halofantrine is an antimalarial drug.
  • Dipalmitolylphosphatidylcholine (DPPC) is a common phospholipid.
  • Understanding drug-lipid interactions is crucial for pharmacodynamics.

Purpose of the Study:

  • To investigate the interaction between halofantrine and DPPC monolayers.
  • To determine the effect of halofantrine concentration and surface pressure on DPPC monolayer penetration.
  • To assess the influence of cholesterol on halofantrine-DPPC interactions.

Main Methods:

  • Studied halofantrine penetration into DPPC monolayers using surface pressure measurements.
  • Varied halofantrine concentrations (0.05-0.2 microm) and initial surface pressures.

Related Experiment Videos

  • Investigated the effect of cholesterol incorporation into DPPC monolayers.

    • Main Results:

    • Halofantrine penetrates DPPC monolayers, increasing surface pressure and area.
    • Penetration is concentration-dependent and more pronounced at low initial surface pressures.
    • Cholesterol significantly reduces halofantrine penetration, especially at high surface pressures (liquid condensed phase).

    Conclusions:

    • Halofantrine readily penetrates DPPC monolayers, supporting its pharmacodynamic profile.
    • Cholesterol acts as a barrier to halofantrine penetration in DPPC monolayers.
    • These findings elucidate halofantrine-phospholipid dynamics and drug behavior.