Related Experiment Video

Updated: Oct 5, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Final height and growth hormone secretion after bone marrow transplantation in children

T Shinagawa1, Y Tomita, H Ishiguro

  • 1Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Kanagawa, Japan.

Endocrine Journal
|July 18, 2001
PubMed

Insights

Children undergoing bone marrow transplantation (BMT) before age 10 risk significant growth failure. Growth hormone (GH) deficiency is not the primary cause of this impaired growth post-BMT.

Area of Science:

  • Pediatric Endocrinology
  • Hematology
  • Oncology

Background:

  • Growth hormone (GH) deficiency is a known factor in growth failure after bone marrow transplantation (BMT).
  • Assessing final height and GH secretion is crucial for understanding long-term outcomes in pediatric BMT survivors.

Purpose of the Study:

  • To analyze final height and GH secretion in children who received BMT.
  • To determine the impact of age at BMT on growth outcomes.
  • To investigate the role of GH deficiency in post-BMT growth impairment.

Main Methods:

  • Retrospective analysis of final height SD scores (SDS) in 30 pediatric BMT patients.
  • Evaluation of GH secretion via repeated insulin tolerance tests in 71 pediatric BMT patients.
  • Comparison of growth outcomes based on age at BMT, disease type, and preconditioning regimen.

Main Results:

  • Final height SDS significantly decreased post-BMT compared to pretreatment.
  • Children transplanted before age 10 experienced greater height reduction.
  • No patient was diagnosed with GH deficiency, though some showed transient poor GH response.

Conclusions:

  • Younger age at BMT increases the risk of growth failure in children.
  • GH deficiency is not a major contributor to growth impairment following BMT.
  • Further research into other factors affecting post-BMT growth is warranted.

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.