Related Experiment Video
Updated: Jul 5, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Kinetic resolution using enantioimpure catalysts: mechanistic considerations of complex rate laws
1Contribution from the Department of Chemistry, University of Hull, Hull HU6 7RX, United Kingdom.
Abstract:
Kinetic resolutions in which the reactions exhibit complex rate laws are discussed. When enantioimpure catalysts are employed, a conversion-dependent selectivity factor k(rel) may in some cases be observed due to "kinetic partitioning" of catalysts within a reaction network. Both asymmetric amplifications and depletions may be observed, and the effects are separate from-and may in some cases be superimposed on-the classic nonlinear effect due to catalyst interactions as those predicted by Kagan's ML(n) models. Consideration of the conversion dependence of the selectivity factor using enantioimpure catalysts reveals significant detail about the reaction mechanism for the enantiopure case and may offer insights for practical application of kinetic resolution. Examples from the literature are analyzed in the context of kinetic partitioning.
More Related Videos
10:54Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
Published on: February 23, 2016
07:37Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening
Published on: May 13, 2020
Related Concept Videos
Rate-Determining Steps
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...
Catalysis
Multi-Step Reactions
Reaction Mechanisms: Rate-limiting Step Approximation
Catalysis
Heterogeneous Catalysis