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Related Experiment Videos

Suicide, impulsive aggression, and HTR1B genotype.

A S New1, J Gelernter, M Goodman

  • 1Psychiatry Service, Bronx VA Medical Center, Bronx, New York 10468, USA.

Biological Psychiatry
|July 18, 2001
PubMed
Summary
This summary is machine-generated.

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Genetic variations in the serotonin 1B receptor gene (HTR1B) may influence suicide attempts in individuals with personality disorders. This study found a specific HTR1B gene allele linked to a history of suicide attempts.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Suicidality and impulsive aggression have partial genetic heritability.
  • Postmortem studies indicate potential links between serotonin 1B receptor abnormalities and suicide.
  • Serotonin 1B receptor knockout mice exhibit increased aggression.

Purpose of the Study:

  • To investigate the association between HTR1B gene variations and suicide history.
  • To examine the relationship between HTR1B genotype and impulsive aggression in personality disorders.

Main Methods:

  • Genotyping at the HTR1B locus was performed.
  • The study assessed suicide history and impulsive aggression in patients with personality disorders.

Main Results:

Related Experiment Videos

  • The 'G' allele of a polymorphic gene at the HTR1B locus was significantly associated with a history of suicide attempts in white patients with personality disorders (p = .01).
  • No significant association was found between HTR1B genotype and self-reported impulsive aggression.

Conclusions:

  • Allelic variability at the HTR1B locus may contribute to the susceptibility for suicide attempts in personality disorder patients.
  • This suggests a potential genetic marker for suicide attempt risk.