Activation of caspase-3/caspase-3-like activity in rat cardiomyocytes by an RGD peptide, but not the GPIIb/IIIa

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Published on: January 12, 2016

J A Erhardt1, E H Ohlstein, J R Toomey

  • 1Department of Cardiovascular Pharmacology, GlaxoSmithKline, King of Prussia, PA 19406, USA. joseph_a_erhardt@sbphrd.com

Thrombosis Research
|July 18, 2001
PubMed
Abstract

No abstract available in PubMed .

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Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.