An introduction to neuronal cholecystokinin

Area of Science:

• Neuroscience
• Endocrinology
• Pharmacology

Background:

• The first Neuronal Cholecystokinin (CCK) Gordon Conference inspired this special issue.
• CCK research has matured, showcasing diverse applications and regulatory mechanisms.

Purpose of the Study:

• To present a comprehensive overview of current CCK research.
• To highlight CCK's multifaceted roles in the brain and body.
• To foster collaboration and advance CCK-based therapies.

Main Methods:

• Review articles covering CCK gene expression, receptor binding, and neurotransmitter interactions.
• Research articles investigating CCK's role in cardiovascular regulation, addiction, and pain.
• Behavioral studies in rodents and sheep examining CCK in learning, memory, and motivated behaviors.

Main Results:

• CCK influences thermoregulation, sexual behavior, satiety, and cardiovascular function.
• CCK A receptor knockout rats exhibit altered cocaine sensitization and satiety.
• CCK levels in cerebrospinal fluid (CSF) are elevated in a chronic pain model.

Conclusions:

• CCK plays significant roles in various physiological and behavioral processes.
• Further research and collaboration are crucial for understanding CCK's full potential.
• CCK-based therapies hold promise for treating neurological and other disorders.