Cholecystokinin and thermoregulation--a minireview
Related Experiment Video
Updated: Oct 5, 2026

Measuring Skeletal Muscle Thermogenesis in Mice and Rats
Published on: July 27, 2022
1Department of Pathophysiology, Faculty of Medicine, University of Pécs, 7624 Pécs, Hungary. szelenyi@apacs.pote.hu
Abstract:
Thermoregulatory effects of cholecystokinin (CCK) peptides are reviewed with special emphasis on two types of responses, that is hypothermia or hyperthermia. In rodents exposed to cold a dose-dependent hypothermia has been observed on peripheral injection of CCK probably acting on CCKA receptors. Central microinjection of CCK in rats induced a thermogenic response that could be attenuated by CCKB receptor antagonists, but some authors observed a hypothermia. It is suggested that neuronal CCK may have a specific role in the development of hyperthermia, and endogenous CCK-ergic mechanisms could contribute to the mediation of fever. Possible connections between thermoregulatory and other autonomic functional changes induced by CCK are discussed.
Related Concept Videos
Hormonal Regulation
Thermoregulation
Thermosensation
Cholecystitis
Regulation of the Digestive System
The effectors in this regulation system are glands and smooth muscles. Activation of these...
Intestinal Phase of Digestion
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
