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[Thyrotoxicosis hepatitis: a case report]
M Bellassoued1, M Mnif, N Kaffel
1Service d'Endocrinologie, CHU Hédi Chaker 3029 Sfax, Tunisie.
Annales D'Endocrinologie
|July 18, 2001
Summary
Thyroid disorders can cause abnormal liver function. This case highlights thyrotoxicosis hepatitis, a reversible liver condition linked to Graves
Area of Science:
- Hepatology
- Endocrinology
Background:
- Thyroid dysfunction, particularly thyrotoxicosis, can manifest with abnormal liver function.
- Liver injury in thyroid disorders may stem from thyrotoxicosis or autoimmune processes.
Observation:
- A 36-year-old female presented with jaundice, pruritus, mild cholestasis, and elevated liver enzymes.
- Graves' disease was diagnosed concurrently with the liver abnormalities.
Findings:
- Laboratory results revealed elevated transaminases, alkaline phosphatase, bilirubin, and gamma-glutamyl transpeptidase.
- Liver biopsy indicated intrahepatic steatosis, anisokaryosis, portal lymphocyte infiltration, and Kupffer cell hyperplasia.
- Other causes of liver disease, including viral hepatitis and autoimmune markers, were ruled out.
Implications:
- This case underscores thyrotoxicosis hepatitis as a potential cause of liver dysfunction in Graves' disease.
- The favorable outcome with iodine therapy suggests the reversibility of this liver condition.
- Highlights the importance of considering thyroid function in unexplained liver abnormalities.