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[Thyrotoxicosis hepatitis: a case report].

M Bellassoued1, M Mnif, N Kaffel

  • 1Service d'Endocrinologie, CHU Hédi Chaker 3029 Sfax, Tunisie.

Annales D'Endocrinologie
|July 18, 2001
PubMed
Summary
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Thyroid disorders can cause abnormal liver function. This case highlights thyrotoxicosis hepatitis, a reversible liver condition linked to Graves

Area of Science:

  • Hepatology
  • Endocrinology

Background:

  • Thyroid dysfunction, particularly thyrotoxicosis, can manifest with abnormal liver function.
  • Liver injury in thyroid disorders may stem from thyrotoxicosis or autoimmune processes.

Observation:

  • A 36-year-old female presented with jaundice, pruritus, mild cholestasis, and elevated liver enzymes.
  • Graves' disease was diagnosed concurrently with the liver abnormalities.

Findings:

  • Laboratory results revealed elevated transaminases, alkaline phosphatase, bilirubin, and gamma-glutamyl transpeptidase.
  • Liver biopsy indicated intrahepatic steatosis, anisokaryosis, portal lymphocyte infiltration, and Kupffer cell hyperplasia.
  • Other causes of liver disease, including viral hepatitis and autoimmune markers, were ruled out.

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Implications:

  • This case underscores thyrotoxicosis hepatitis as a potential cause of liver dysfunction in Graves' disease.
  • The favorable outcome with iodine therapy suggests the reversibility of this liver condition.
  • Highlights the importance of considering thyroid function in unexplained liver abnormalities.