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Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

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Stem cell engraftment strategies.

P J Quesenberry¹, F M Stewart, P Becker

¹Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

Annals of the New York Academy of Sciences

|July 19, 2001

Summary

Stem cell transplant success depends on donor cell traits and the host environment. Donor stem cell plasticity, influenced by factors like circadian rhythm, significantly impacts engraftment and transplant outcomes.

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Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity

Published on: July 10, 2019

Area of Science:

Hematology
Immunology
Transplantation Biology

Background:

Stem cell transplant outcomes are dictated by donor cell characteristics and the recipient's microenvironment.
Understanding factors influencing stem cell engraftment is crucial for improving transplant efficacy.

Purpose of the Study:

To investigate the determinants of stem cell engraftment in various transplant models.
To explore the plasticity of donor stem cell phenotype and its impact on transplant success.

Main Methods:

Utilized syngeneic and congenic mouse models with minimal irradiation.
Employed antigen pre-exposure and CD40-CD40 ligand antibody blockade in allogeneic models.
Analyzed a human trial involving patients with resistant neoplasia receiving apheresed blood.

Main Results:

Syngeneic engraftment is primarily driven by stem cell competition.
Allogeneic transplantation is feasible in H-2 mismatched combinations with specific interventions.
Human trials show tumor responses and chimerism with low CD34+ cell doses, influenced by prior treatment.
Donor stem cell phenotype exhibits reversible plasticity affecting differentiation, adhesion, and engraftment.
Engraftment capacity fluctuates with marrow circadian rhythm.

Conclusions:

Stem cell competition is a key factor in syngeneic engraftment.
Donor stem cell phenotype plasticity and host factors critically influence transplant outcomes.
Circadian rhythms and prior patient treatment impact engraftment and chimerism.