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Neurokinin-1 receptor antagonists block acute cocaine-induced horizontal locomotion
M Kraft1, S Ahluwahlia, J A Angulo
1Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA.
Annals of the New York Academy of Sciences
|July 19, 2001
Abstract:
Systemic exposure to neurokinin-1 receptor antagonists CP099994 or LY306740 prior to cocaine administration (10 mg/kg i.p.) blocks acute, cocaine-induced horizontal locomotion. CP099994 (30 mg/kg) was delivered i.p. 30 minutes before cocaine exposure, and LY306740 (5 mg/kg) was delivered continuously by osmotic minipump for 12-14 hours before cocaine administration. These results suggest that endogenous substance P acting via neurokinin-1 receptors is necessary for the expression of acute cocaine-induced hyperactivity.