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[Adult celiac disease].

C Cellier1, E Grosdidier

  • 1Service d'hépato-gastroentérologie Hôpital Européen Georges-Pompidou 75908 Paris. christophe.cellier@egp.ap-hop-paris.fr

La Revue Du Praticien
|July 19, 2001
PubMed
Summary

Celiac disease affects 1 in 300 people and often presents with subtle symptoms. Early diagnosis through antibody testing and consideration of non-gastrointestinal signs are crucial for effective management.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Internal Medicine

Context:

  • Celiac disease prevalence is higher than previously recognized, affecting approximately 1 in 300 individuals.
  • Many cases are asymptomatic or exhibit non-classical symptoms, leading to delayed diagnosis.
  • Diagnosis should be considered in adults with unexplained iron deficiency anemia, neurological issues, osteoporosis, infertility, or dermatitis herpetiformis.

Purpose:

  • To highlight the increased prevalence and varied clinical presentations of celiac disease.
  • To emphasize the importance of considering celiac disease in adults with specific non-gastrointestinal symptoms.
  • To outline diagnostic criteria, including characteristic histology and serological markers.

Summary:

  • Celiac disease is common, often with mild or silent symptoms, and diarrhea is infrequent.
  • Key diagnostic indicators include villous atrophy, increased intraepithelial lymphocytes, and positive endomysial and transglutaminase IgA antibodies.
  • A strict gluten-free diet is the primary treatment, though refractory cases require further consideration for complications like intestinal lymphoma.

Impact:

  • Increased awareness can lead to earlier diagnosis and intervention for celiac disease patients.
  • Improved diagnostic strategies can reduce the long-term complications associated with untreated celiac disease.
  • Understanding the diverse clinical manifestations aids healthcare providers in identifying at-risk individuals.

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