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Related Experiment Videos

Acute phase response in naturally occurring coliform mastitis.

H Ohtsuka1, K Kudo, K Mori

  • 1Department of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan.

The Journal of Veterinary Medical Science
|July 19, 2001
PubMed
Summary

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Severe coliform mastitis in dairy cows causes significant changes in serum cytokines like interleukin-1 (IL-1) and acute phase proteins, including alpha-1-acidglycoprotein (alpha1AG) and haptoglobin (Hp). These markers indicate a prolonged inflammatory response in severe cases.

Area of Science:

  • Veterinary Immunology
  • Bovine Infectious Diseases
  • Dairy Cattle Health

Background:

  • Coliform mastitis is a significant challenge in dairy herds, impacting cow health and milk production.
  • Understanding the systemic inflammatory response is crucial for managing severe cases.

Purpose of the Study:

  • To investigate dynamic changes in serum cytokines and acute phase proteins in dairy cows with naturally occurring coliform mastitis.
  • To differentiate inflammatory responses between mild and severe mastitis cases.

Main Methods:

  • Serum samples were collected from dairy cows diagnosed with coliform mastitis.
  • Activities of serum cytokines, including interleukin-1 (IL-1) and tumor necrosis factor (TNF), were measured.
  • Concentrations of acute phase proteins, alpha-1-acidglycoprotein (alpha1AG) and haptoglobin (Hp), were determined.

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Main Results:

  • Cows with severe mastitis exhibited higher serum IL-1 and TNF activities compared to mild cases at symptom onset.
  • Elevated IL-1 activity persisted throughout the observation period in the severe group.
  • Serum alpha1AG peaked at 9 days, and serum Hp peaked at 3 days in severe mastitis cases.

Conclusions:

  • Dynamic changes in serum IL-1, alpha1AG, and Hp reflect the severity and duration of inflammatory response in coliform mastitis.
  • These biomarkers can aid in assessing disease progression and prognosis in affected dairy cows.