Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Allopurinol augmentation for poorly responsive schizophrenia.

D R Lara1, M G Brunstein, E S Ghisolfi

  • 1Department of Biochemistry, ICBS, UFRGS, Porto Alegre, Brazil. drlara@plug-in.com.br

International Clinical Psychopharmacology
|July 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of dental anatomy knowledge among dental students: A preliminary study.

Morphologie : bulletin de l'Association des anatomistes·2024
Same author

Guanosine enhances glutamate uptake and oxidation, preventing oxidative stress in mouse hippocampal slices submitted to high glutamate levels.

Brain research·2020
Same author

Behavioral, Neurochemical and Brain Oscillation Abnormalities in an Experimental Model of Acute Liver Failure.

Neuroscience·2019
Same author

Corrigendum to "Cannabinoid Receptor Agonists Reduce the Short-Term Mitochondrial Dysfunction and Oxidative Stress Linked to Excitotoxicity in the Rat Brain" [Neuroscience 285C (2015) 97-106].

Neuroscience·2018
Same author

Phytosterol-enriched milk lowers LDL-cholesterol levels in Brazilian children and adolescents: Double-blind, cross-over trial.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2017
Same author

More than words: The association of childhood emotional abuse and suicidal behavior.

European psychiatry : the journal of the Association of European Psychiatrists·2016

Allopurinol, a purine degradation inhibitor, may improve schizophrenia symptoms by indirectly increasing adenosine levels. Two schizophrenia patients showed significant improvement with add-on allopurinol, suggesting its therapeutic potential.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Adenosine's role in schizophrenia pathophysiology is increasingly recognized.
  • Targeting the adenosine system presents a potential therapeutic avenue for schizophrenia.
  • Direct adenosine agonists are limited, necessitating alternative strategies.

Observation:

  • Two patients with treatment-resistant schizophrenia were treated with allopurinol.
  • Allopurinol was administered as an add-on therapy at 300 mg/day.
  • Significant clinical improvements were observed in both patients.

Findings:

  • Allopurinol, by inhibiting purine degradation, may indirectly modulate adenosine levels.
  • Add-on allopurinol demonstrated notable efficacy in improving schizophrenia symptoms in these cases.

Related Experiment Videos

  • The observed improvements suggest a potential role for purinergic modulation in schizophrenia treatment.

    • Implications:

    • Allopurinol warrants further investigation as a potential treatment for schizophrenia.
    • Exploring other purinergic strategies could offer novel therapeutic approaches for schizophrenia.
    • These findings open new avenues for understanding and treating schizophrenia through purinergic system modulation.