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Inhibition of fucosyltransferase V by a GDP-Azasugar
1Institut für Organische Chemie, Sekr. C3, Technische Universität Berlin, Strasse des 17. Juni 135, D-10623, Berlin, Germany. mschuster@chem.tu-berlin.de
Bioorganic & Medicinal Chemistry Letters
|July 19, 2001
Abstract:
A GDP-azasugar conjugate was synthesized starting from an enzymatically obtained phosphorylated azasugar. It inhibits human fucosyltransferase V at micromolar concentrations, which is discussed in terms of transition state analogy.