Nitrobenzene compounds inhibit expression of VCAM-1
C Q Meng1, X S Zheng, L A Holt
1AtheroGenics, Inc., 8995 Westdise Parkway, 30004, Alpharetta, GA, USA. cmeng@atherogenics.com
Bioorganic & Medicinal Chemistry Letters
|July 19, 2001
Abstract:
A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.
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