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Related Experiment Videos

Reproducibility of quantitative CT perfusion imaging.

J H Gillard1, N M Antoun, N G Burnet

  • 1Departments of Radiology, Oncology and Neurosurgery, Addenbrooke's Hospital and the University of Cambridge, Cambridge CB2 2QQ, UK.

The British Journal of Radiology
|July 19, 2001
PubMed
Summary

CT perfusion imaging offers quantifiable cerebral blood flow measurements without specialized equipment. This technique shows minimal day-to-day variability in cerebral blood flow values, aiding stroke diagnosis and treatment.

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Area of Science:

  • Radiology
  • Neurology
  • Medical Imaging

Background:

  • Assessing abnormal cerebral blood flow is crucial for acute stroke diagnosis, prognosis, and therapeutic decisions.
  • CT perfusion imaging provides quantifiable cerebral blood flow (CBF) measurements using standard CT scanners.
  • The day-to-day variability of CBF values from CT perfusion imaging requires assessment for clinical reliability.

Purpose of the Study:

  • To evaluate the day-to-day variability of cerebral blood volume (CBV) and cerebral blood flow (CBF) measurements using CT perfusion imaging.
  • To determine the reliability of CT perfusion imaging for assessing cerebral hemodynamics over a 24-hour period.

Main Methods:

  • Dynamic CT perfusion imaging was performed on seven patients with cerebral gliomas on two separate occasions, approximately 24 hours apart.

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  • Regions of interest (ROIs) were defined in middle cerebral artery territories in both hemispheres for each study.
  • Absolute CBF values were calculated for these ROIs and correlated between the two imaging sessions.

    • Main Results:

    • A high Pearson correlation coefficient of 0.884 was obtained when comparing CBF values from the initial and follow-up studies.
    • CT perfusion imaging demonstrated minimal variability in absolute CBF measurements within individuals over a 24-hour interval.
    • The technique is readily performable on conventional modern CT equipment.

    Conclusions:

    • CT perfusion imaging is a reliable method for assessing cerebral blood flow with low day-to-day variability.
    • The technique's ease of use and minimal variability support its utility in clinical settings for stroke evaluation and management.
    • Quantifiable CBF data from CT perfusion imaging can aid in diagnostic and prognostic assessments for acute stroke patients.