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[Panniculitis induced by MINE chemotherapy].

I Saint-Cyr1, G Vezon, A M Boisseau-Garsaud

  • 1Service de Dermatologie, CHU de Fort-de-France, Hôpital Pierre-Zobda-Quitman, BP 632, 97261 Fort de France Cedex, Martinique.

Annales De Dermatologie Et De Venereologie
|July 19, 2001
PubMed
Summary

Drug-induced panniculitis is rare. This report details a second case of panniculitis caused by MINE chemotherapy in a patient with Hodgkin disease, highlighting a rare adverse effect.

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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Drug-induced panniculitis is an uncommon adverse reaction to various medications.
  • MINE chemotherapy is a cytostatic regimen used for relapsed Hodgkin disease.
  • Cutaneous adverse effects of MINE chemotherapy are infrequent, with rash and erythema being more common.

Observation:

  • A 31-year-old woman with relapsed Hodgkin disease developed panniculitis during MINE chemotherapy.
  • Erythematous, painful nodules appeared on her chest, abdomen, and thighs 15 days after initiating treatment.
  • A second flare-up occurred after the second administration of MINE chemotherapy.

Findings:

  • This represents the second reported case of panniculitis induced by MINE chemotherapy.
  • The panniculitis eruption resolved slowly after the withdrawal of MINE chemotherapy.

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  • Other reported drug-induced panniculitis cases involve treatments like steroids, atenolol, and immunotherapy.

    • Implications:

    • This case expands the known spectrum of cutaneous adverse effects associated with MINE chemotherapy.
    • Clinicians should be aware of the potential for MINE chemotherapy to induce panniculitis, even if rare.
    • Prompt recognition and discontinuation of the drug may lead to resolution of this uncommon side effect.