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Plasma cell differentiation requires the transcription factor XBP-1

A M Reimold1, N N Iwakoshi, J Manis

  • 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

Nature
|July 19, 2001
PubMed
Summary

The transcription factor XBP-1 is essential for the development of antibody-secreting plasma cells. Without XBP-1, B cells cannot differentiate, leading to impaired immunity.

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