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Denatured plasma and platelet function.

H W Wallace, E M Liquori, T P Stein

    Transactions - American Society for Artificial Internal Organs
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Extracorporeal circulation can cause low platelet counts and dysfunction. Denatured proteins from this process may impair platelet aggregation, potentially explaining these complications.

    Area of Science:

    • Biochemistry
    • Hematology
    • Medical Devices

    Background:

    • Extracorporeal circulation (ECC) is associated with thrombocytopenia and platelet dysfunction.
    • Protein denaturation occurs during ECC, even without a blood-gas interface.

    Purpose of the Study:

    • To investigate the impact of "denatured" plasma on platelet function.
    • To determine if denatured proteins contribute to ECC-related platelet complications.

    Main Methods:

    • Platelet-poor plasma was subjected to vigorous air bubbling to induce protein denaturation.
    • The effect of this "denatured" plasma on platelet aggregation (induced by ADP, epinephrine, and collagen) was measured.

    Main Results:

    • "Denatured" plasma reduced the lag time for collagen-induced platelet aggregation.

    Related Experiment Videos

  • "Denatured" plasma abolished the biphasic aggregation response to epinephrine.
  • These changes suggest impaired platelet responsiveness.

    • Conclusions:

    • Denatured proteins generated during extracorporeal circulation may alter platelet function.
    • These protein alterations could contribute to the thrombocytopenia and dysfunction observed with ECC.