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Updated: Aug 12, 2026

Intracranial Injection of Adeno-associated Viral Vectors
Published on: November 17, 2010
[Cerebral arterial aneurysm in a child with acquired immunodeficiency syndrome: case report]
Carvalho Neto Ad1, I Bruck, L O Coelho
1Disciplina de Radiologia, Departamento de Clínica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Abstract:
Cerebral aneurysmal arteriopathy of the circle of Willis is an uncommon manifestation of acquired human immunodeficiency virus (HIV) infection and up to now only 15 cases have been published in the literature. For this reason we add our experience of this rare case, and review the most important aspects related to this entity. The patient is a 6 year old male with perinatal transmitted AIDS, tetraparethic, developed symptoms characterized by episodes of dystonic postures. The computed tomography of the brain showed aneurismal arteriopathy of the circle of Willis. He had a previous normal examination. The review of the literature shows the pathological abnormalities of the affected vessels are mainly medial fibrosis, with destruction of the internal elastic lamina and intimal hyperplasia. The etiology for the vasculitis is unknown. Varicela zoster virus, as well as HIV by itself, can be related to the physiopathology of the vasculitis. On conclusion, it can be said that although uncommon, such complications are of great importance by the fact that the patients with vascular aneurismal arteriopathy are in high risk for vascular accidents, and once a diagnosis was made, death occurs in less than 6 months, according to the literature.
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