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Formed element deposition onto filtering walls.

R J Forstrom, K Bartelt, P L Blackshear

Transactions - American Society for Artificial Internal Organs

|January 1, 1975

Summary

Particle deposition on filters depends on a specific parameter. Erythrocytes deposit above 0.15, while platelets deposit between 0.01 and 0.15, with fluid mechanics potentially enhancing platelet surface adherence.

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Area of Science:

Biomedical Engineering
Fluid Mechanics
Materials Science

Background:

Particle deposition on filtering surfaces is crucial in various applications, including medical devices and water purification.
Understanding the factors influencing particle adhesion is essential for optimizing filtration efficiency and preventing device fouling.
Erythrocytes and platelets exhibit different deposition behaviors, necessitating distinct criteria for predicting their adherence.

Purpose of the Study:

To investigate the critical non-dimensional parameter governing particle deposition onto filtering surfaces.
To compare the deposition thresholds for erythrocytes and platelets.
To explore the role of fluid mechanics in platelet transport and adherence to surfaces.

Main Methods:

Analysis of particle transport and deposition using a non-dimensional parameter (U R²S³/²).
Experimental determination of deposition thresholds for erythrocytes and platelets.
Modeling of fluid mechanical forces influencing platelet-surface interactions.

Main Results:

A critical value of the non-dimensional parameter (U R²S³/²) predicts particle deposition.
Erythrocytes require a value of 0.15 for deposition, whereas platelets deposit within a range of 0.01 to 0.15.
Fluid mechanical mechanisms, beyond simple adhesion, are expected to significantly contribute to platelet transport and surface retention.

Conclusions:

The non-dimensional parameter U R²S³/² effectively predicts particle deposition thresholds for erythrocytes and platelets.
Platelet deposition is influenced by a broader range of conditions compared to erythrocytes.
Fluid mechanics plays a significant role in platelet adherence, suggesting that even non-sticky surfaces can retain platelets through hydrodynamic forces.

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