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A database for human fibrinogen variants.

M Hanss1, F Biot

  • 1Laboratoire d'hématologie, Hôpital Cardiologique, Lyon, France. michel.hanss@chu-lyon.fr

Annals of the New York Academy of Sciences
|July 20, 2001
PubMed
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Studying abnormal human fibrinogens provides valuable insights for patient care. An extensive online register catalogs these molecular abnormalities and their clinical features for easy access and updates.

Area of Science:

  • Biochemistry
  • Hematology
  • Medical Genetics

Background:

  • Human fibrinogen is crucial for blood clotting.
  • Molecular abnormalities in fibrinogen can lead to bleeding disorders or thrombosis.
  • Understanding these variations is key for diagnosis and management.

Purpose of the Study:

  • To compile and maintain a comprehensive register of abnormal human fibrinogens.
  • To facilitate easy access to information on fibrinogen molecular abnormalities.
  • To correlate genetic defects with clinical manifestations.

Main Methods:

  • Systematic review of literature on fibrinogen abnormalities.
  • Database compilation of identified molecular defects.
  • Inclusion of clinical features associated with each abnormality.

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Main Results:

  • An extensive online register of human fibrinogen abnormalities has been created.
  • The register includes detailed information on known molecular defects.
  • Essential clinical features are linked to specific fibrinogen abnormalities.

Conclusions:

  • The online register serves as a valuable resource for researchers and clinicians.
  • It aids in the identification and study of abnormal human fibrinogens.
  • This resource supports improved patient care for individuals with fibrinogen disorders.