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Related Experiment Videos

Hypoglycemia risk reduction in type 1 diabetes.

P E Cryer1

  • 1Division of Endocrinology, Diabetes and Metabolism, General Clinical Research Center, Diabetes Research and Training Center, Washington University School of Medicine, St. Louis, Missouri, USA. pcryer@imgate.wustl.edu

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|July 20, 2001
PubMed
Summary

Hypoglycemia is a major challenge in managing type 1 diabetes mellitus (T1 DM). Aggressive therapy and risk reduction strategies can improve glycemic control while minimizing dangerous low blood sugar events.

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Diabetologia·2008
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Comment on: Nathan DM, Buse JB, Davidson MB et al (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711-1721.

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Hypoglycaemia: the limiting factor in the glycaemic management of the critically ill?

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The pathophysiology of hypoglycaemia in diabetes.

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Hypoglycemia-associated autonomic failure in diabetes.

American journal of physiology. Endocrinology and metabolism·2001

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetes Management

Background:

  • Hypoglycemia limits glycemic control in type 1 diabetes mellitus (T1 DM).
  • Aggressive therapy, while beneficial, can increase hypoglycemia risk.
  • Compromised glucose counterregulation and hypoglycemia unawareness are key issues.

Purpose of the Study:

  • To explore the relationship between aggressive glycemic control and hypoglycemia in T1 DM.
  • To identify risk factors for severe hypoglycemia in T1 DM.
  • To propose strategies for minimizing hypoglycemia while optimizing glycemic management.

Main Methods:

  • Review of conventional and potent risk factors for hypoglycemia.
  • Analysis of the concept of hypoglycemia-associated autonomic failure in T1 DM.

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  • Discussion of hypoglycemia risk reduction strategies.

    • Main Results:

    • Conventional risk factors explain only a minority of severe hypoglycemia episodes.
    • Absolute insulin deficiency, history of severe hypoglycemia, and aggressive therapy are potent risk factors.
    • Hypoglycemia-associated autonomic failure creates a vicious cycle of recurrent hypoglycemia.

    Conclusions:

    • Improving glycemic control and minimizing hypoglycemia in T1 DM are achievable goals.
    • A comprehensive approach addressing patient concerns, risk factors, and regimen adjustments is crucial.
    • Scrupulous avoidance of hypoglycemia for 2-3 weeks can benefit patients with autonomic failure.