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Birth weight and parental PGM1 alleles
F Gloria-Bottini1, N Lucarini, M La Torre
1Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy.
Summary
Maternal and neonatal phosphoglucomutase locus 1 (PGM1) genotype influenced intrauterine growth, particularly in female infants. The paternal PGM1*2 allele was linked to reduced risk of macrosomia in female newborns.
Area of Science:
- Genetics
- Reproductive Biology
- Perinatal Medicine
Background:
- The distribution of the phosphoglucomutase locus 1 (PGM1) in mothers and newborns deviates from Hardy-Weinberg expectations.
- Intrauterine selection pressures on PGM1 alleles have been hypothesized to explain these deviations.
- Maternal and paternal PGM1 alleles may differentially impact intrauterine survival.
Purpose of the Study:
- To investigate the association between joint maternal-neonatal PGM1 genotype and intrauterine growth.
- To determine if PGM1 genotype influences birth weight and the risk of macrosomia.
Main Methods:
- Analysis of joint maternal-neonatal PGM1 genotypes.
- Assessment of birth weight percentile classes.
- Evaluation of the association between PGM1 alleles and macrosomia, stratified by infant sex.
Main Results:
- A significant association was found between birth weight percentile class and maternal-neonatal PGM1 genotype in female infants.
- The paternal PGM1*2 allele showed a significant negative association with macrosomia, specifically in female infants.
Conclusions:
- Maternal-neonatal PGM1 genotype is associated with intrauterine growth, especially in female neonates.
- The paternal PGM1*2 allele may offer protection against macrosomia in female infants, suggesting sex-specific genetic influences on fetal development.