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Updated: Oct 5, 2026

Reliable Creation of a Murine Abdominal Aortic Aneurysm Model Using Elastin Sensitization and Perivascular Elastase
Published on: June 26, 2026
Serum levels of elastin-derived peptides in patients with ruptured and asymptomatic abdominal aortic aneurysms
E Petersen1, A Gineitis, F Wågberg
1Department of Surgery, Umeå University Hospital, Umeå, Sweden.
Objective:
to determine whether serum elastin-derived peptides (S-EDP), are lower in patients with ruptured abdominal aortic aneurysms (rAAA) than asymptomatic (aAAA).
Materials And Methods:
serum samples were collected preoperatively from 45 consecutive patients with aAAA and 15 haemodynamically stable patients with rAAA. S-EDP (ng/ml) was measured by a competitive enzyme-linked immunosorbent assay (ELISA).
Results:
S-EDP (mean +/- s.d.) was significantly lower in patients with rAAA (31.6 ng/ml +/- 6.8) than in patients with aAAA (39.4 ng/ml +/- 8.0 p=0.001).
Conclusion:
patients with rAAA had significantly lower levels of S-EDP than patients with aAAA. The possibility that S-EDP can be used to identify patients at increased risk of rupture requires further investigation.
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