Related Experiment Video
Updated: Oct 5, 2026
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Pathophysiology of proximal perigraft endoleak following endovascular repair of abdominal aortic aneurysms: a study
J N Albertini1, J A Macierewicz, S W Yusuf
1Vascular Surgery Department, Queen's Medical Centre, Nottingham, UK.
Objective:
to design a flow model to determine whether and why increased proximal neck angulation correlates with increased risk of proximal perigraft endoleak (PPE) flow.
Methods:
a tapered stent-graft (Gianturco stent + Dacron) was deployed with proximal and distal necks made of silicone. The amount of PPE was measured over 30-s periods while the angulation of the proximal neck was increased.
Results:
PPE flow increased significantly for angulations > or =30 degrees. The graft was lifted off the neck wall and gaps between the stent-graft and the neck created.
Conclusion:
greater neck angulation increased PPE flow. The stent-graft was lifted off the neck and subsequent gaps created. This model could be used to compare available stent-grafts and to test new designs that would improve the seal in angulated necks.
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