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Related Experiment Videos

Corticosteroids and cognition.

J K Belanoff1, K Gross, A Yager

  • 1Stanford University School of Medicine, Department of Psychiatry, Stanford, CA 94305, USA. belanoff@leland.stanford.edu

Journal of Psychiatric Research
|July 20, 2001
PubMed
Summary
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High corticosteroid levels impair cognition, particularly in the hippocampus and frontal lobes. This review explores glucocorticosteroid effects on cognitive functions and potential pharmacological management strategies.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Cognitive Psychology

Background:

  • The brain is a primary target for corticosteroids.
  • Elevated corticosteroid levels are linked to cognitive impairment across various diseases.
  • The impact of low corticosteroid levels on cognition is less understood.

Purpose of the Study:

  • To review existing literature on glucocorticosteroid effects on cognition.
  • To identify specific cognitive functions causally affected by glucocorticosteroids.
  • To explore potential brain regions involved in glucocorticosteroid-induced cognitive dysfunction.

Main Methods:

  • Literature review of studies on glucocorticosteroids and cognition.
  • Analysis of clinical disease states associated with corticosteroid levels and cognitive function.

Related Experiment Videos

  • Examination of neuroanatomical correlates of glucocorticosteroid effects.

    • Main Results:

    • Excessive corticosteroids are frequently associated with cognitive impairment.
    • Specific cognitive functions are identified as being causally affected.
    • The hippocampus and frontal lobe regions are implicated in glucocorticosteroid-induced brain perturbation.

    Conclusions:

    • Glucocorticosteroids significantly impact cognitive functions.
    • Cognitive dysfunction may be linked to specific brain regions like the hippocampus and frontal lobes.
    • Pharmacological interventions may offer a way to manage glucocorticosteroid-related cognitive deficits.