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Role for p53 in gene induction by double-stranded RNA
B T Hummer1, X L Li, B A Hassel
1Greenebaum Cancer Center, The University of Maryland, Baltimore, Maryland 21201, USA.
Journal of Virology
|July 20, 2001
Abstract:
Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.