Related Experiment Video
Updated: Aug 7, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Toward the total synthesis of variecolin
G A Molander1, M S Quirmbach, L F Silva
1Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA. gmolandr@sas.upenn.edu
Abstract:
[reaction: see text] An annulative approach toward the total synthesis of the sesterterpenoid variecolin (1) is presented. Synthesis of the key hemiketal, containing the core ABC ring skeleton, has been achieved on a model system by an expeditious route utilizing samarium(II) iodide. Furthermore, enantioselective syntheses of component fragments for the total synthesis have been developed.
Related Concept Videos
Synthesis and Decomposition Reactions
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Cycloaddition Reactions: Overview
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement
Aryldiazonium Salts to Azo Dyes: Diazo Coupling

