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Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors
1Center for Molecular Catalysis, School of Chemistry & Molecular Engineering, Seoul National University, Seoul, 151-747, Korea. kimbm@snu.ac.kr
Organic Letters
|July 21, 2001
Abstract:
[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.