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Scavenging of fluorinated N,N'-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis
C Palomo1, J M Aizpurua, I Loinaz
1Departamento de Química Orgánica-I, Universidad del País Vasco, Facultad de Química, Apdo 1072, 20080 San Sebastián, Spain. qppaiipj@sc.ehu.es
Organic Letters
|July 21, 2001
Abstract:
[reaction: see text] A dramatic solubility increase in fluorous solvents is observed for N,N'-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separation method.