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Tetrasomy 21 as the sole acquired karyotypic abnormality in acute myeloblastic leukemia
T Odagaki1, T Sugimoto, M Matsuo
1Section of Internal Medicine, Kobe Kyodo Hospital, 2-Kubo-cho, Nagata-ku, 653-0041, Kobe, Japan.
Cancer Genetics and Cytogenetics
|July 21, 2001
Abstract:
Peripheral blood and bone marrow analysis of a 79-year-old female led to a diagnosis of acute myeloblastic leukemia with differentiation (AML-M2). Chromosome analysis of the unstimulated bone marrow cells revealed 48, XX,+21,+21, and tetrasomy 21 was the sole cytogenetic abnormality in this constitutionally normal female patient.