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Updated: Aug 10, 2026
In Vitro Assay of Bacterial Adhesion onto Mammalian Epithelial Cells
Published on: May 16, 2011
Effect of cyclosporin on uropathogenic Escherichia coli adherence to human endothelial cells
1Institute of Microbiology and Infectious Diseases, Karol Marcinkowski University of Medical Sciences in Poznan, Wieniawskiego 3, 61-712, Poznan, Poland.
Abstract:
The effect of cyclosporin A on the adherence of Escherichia coli strains to human umbilical vein endothelial cells was studied. Compared with the controls, bacterial adherence significantly increased following preincubation of the cells with cyclosporin A at 50 mg/l and more significantly, to cells preincubated with cyclosporin A at 100-200 mg/l. The results showed that cyclosporin A use may be accompanied by an increased bacterial adherence to host cells in vivo. This effect was achieved using a wide range of therapeutic doses.
