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Related Experiment Videos

Celecoxib-induced Sweet's syndrome.

K H Fye1, E Crowley, T G Berger

  • 1Division of Rheumatology, Department of Medicine, University of California, San Francisco, USA.

Journal of the American Academy of Dermatology
|July 21, 2001
PubMed
Summary
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A man developed Sweet's syndrome, a skin condition, after taking celecoxib, a new arthritis medication. Lesions cleared after stopping the drug, indicating a potential drug-induced reaction.

Area of Science:

  • Dermatology
  • Rheumatology

Background:

  • Sweet's syndrome is a neutrophilic dermatosis linked to various medications.
  • Celecoxib is a selective cyclo-oxygenase-2 inhibitor used for arthritis.

Observation:

  • A 57-year-old male presented with tender pustulopapular lesions on hands, neck, and legs.
  • Symptoms appeared one week after initiating celecoxib therapy.

Findings:

  • Histopathology revealed diffuse dermal neutrophilic infiltrate, papillary dermal edema, and spongiform pustules, consistent with Sweet's syndrome.
  • The patient experienced rapid lesion exacerbation upon rechallenge with celecoxib.
  • Complete resolution of lesions occurred after drug discontinuation.

Implications:

Related Experiment Videos

  • This case suggests a potential association between celecoxib and Sweet's syndrome.
  • This is the first reported instance of Sweet's syndrome linked to a COX-2 inhibitor.
  • Clinicians should consider celecoxib as a potential trigger for Sweet's syndrome in patients presenting with characteristic lesions.