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Patch testing discordance alert: false-negative findings with rubber additives and fragrances
E F Sherertz1, A F Fransway, D V Belsito
1Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Patch testing for contact dermatitis revealed discrepancies between Finn Chambers and T.R.U.E. Test systems. Using T.R.U.E. Test alone may miss reactions to common allergens like fragrances.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis
Background:
- Contact dermatitis is a common skin condition.
- Accurate diagnosis relies on effective patch testing.
Purpose of the Study:
- To compare the diagnostic accuracy of Finn Chambers and the T.R.U.E. Test allergen system.
- To identify potential discrepancies in patch testing results.
Main Methods:
- Simultaneous patch testing of 318 patients using Finn Chambers and T.R.U.E. Test.
- Evaluation of results for suspected contact dermatitis.
Main Results:
- Discrepancies were observed between the two patch testing systems.
- Particular differences noted for fragrance and rubber allergens.
- T.R.U.E. Test alone may underdiagnose reactions to fragrance, thiuram, and carba mix.
Conclusions:
- Finn Chambers and T.R.U.E. Test show variable performance.
- Caution is advised when using T.R.U.E. Test exclusively for certain allergens.
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