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Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
Published on: May 31, 2011
Discriminant analysis and its application in DNA sequence motif recognition
1Cold Spring Harbor Laboratory, Watson School of Biological Sciences, NY 11724, USA. Mzhang@cshl.org
Abstract:
Identification of functional motifs in a DNA sequence is fundamentally a statistical pattern recognition problem. Discriminant analysis is widely used for solving such problems. This paper will review two basic parametric methods: LDA (linear discriminant analysis) and QDA (quadratic discriminant analysis). Their usage in recognition of splice sites and exons in the human genome will be demonstrated.
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