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Total synthesis of agosterol A: an MDR-modulator from a marine sponge
N Murakami1, M Sugimoto, M Morita
1Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 24, 2001
Abstract:
The first total synthesis of agosterol A, a modulator of multidrug resistance (MDR) mediated by P-gp and MRP1, and isolated from a marine sponge, was achieved from ergosterol by utilizing a regioselective epoxy-cleavage reaction and regioselective dehydroxylation as the key reactions.